Essential Tremor

Essential Tremor



Currently there are no effective medication for essential tremor except for propanalol and primidone, both of which have strong side effects causing sleepiness that may interfere with daily living activities.  This study is to evaluate the dose-response relationship of different doses of SAGE-324 on upper extremity tremor as measured by tetras performance scale difference between baseline and day 91.

Key procedures:

ECGS - day1 – ECG supine and standing every 15 min. Hematology and urine – PK possible.

Full details:

For full details on this study, please contact us at (786) 432-3200. 

Essential Tremor

Essential Tremor, often abbreviated as ET, is a neurological disorder characterized by involuntary rhythmic shaking or trembling of certain parts of the body, typically the hands but potentially involving the head, voice, or other areas as well. This type of tremor is often referred to as “essential” because in the Essential Tremor Clinical Research Trials nothing came out and found that it is not associated with any underlying medical condition and its exact cause is not fully understood.


Essential Tremor is one of the most common movement disorders, affecting millions of people worldwide. The tremor is usually more pronounced during activities that require fine motor skills, such as holding objects or performing tasks that involve precise hand movements. It can vary in severity from mild to disabling, causing difficulties in daily activities like eating, drinking, writing, and even speaking in severe cases.

The tremor associated with essential tremor tends to have a characteristic appearance of a rhythmic back-and-forth motion, typically occurring at a frequency of 4-12 hertz. It can also be enhanced by stress, fatigue, caffeine, and certain medications.

While the exact cause of essential tremor is still not fully understood, it is believed to involve a combination of genetic and environmental factors. It often runs in families, suggesting a genetic predisposition. The tremor is thought to originate in the brain’s cerebellum, which is responsible for coordinating movement. 

There is no cure for Essential Tremor, but treatment options are available to manage the symptoms and improve quality of life. These may include medications that help reduce the severity of the tremor, such as beta-blockers and anticonvulsants. In cases where medication is not effective, other interventions like deep brain stimulation (DBS) may be considered. DBS involves surgically implanting electrodes into specific areas of the brain to modulate abnormal neural activity and reduce tremor.

It’s important to differentiate essential tremor from other types of tremors, such as those caused by Parkinson’s disease or other neurological conditions, as treatment approaches may differ. A proper Essential Tremor Treatment from a medical professional, often a neurologist, is crucial for determining the appropriate course of action.