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Summary
Intro:
COPD is characterized by respiratory symptoms and airflow limitations usually caused by significant exposure to smoking. 80-90% of individuals who have smoked have COPD. To date, there are several single fixed triple -dose inhalers that are FDA approved. This trial will compare a triple dose inhaler with a double-dose inhaler to reduce the number of COPD exacerbations.
Participant patient:
40 yrs. of age or older, current, or previous smoking, COPD diagnosis for at least 12 months before screening.
Key procedures:
CT scan of chest. Blood draw.
Full details:
COPD
Chronic obstructive pulmonary disease (COPD) is a progressive lung disorder characterized by persistent airflow limitation that makes breathing difficult. It’s a collective term for a group of lung conditions that includes chronic bronchitis and emphysema. The main characteristic of COPD is reduced airflow in and out of the lungs, making it challenging to exhale effectively.
Description:
COPD is a common and serious lung disease that primarily affects individuals who have a history of smoking or prolonged exposure to lung irritants, such as industrial dust, pollution, or chemical fumes. In some cases, genetic factors can also play a role. The disease typically develops slowly over many years and worsens over time.
Chronic bronchitis:
This aspect of COPD involves inflammation and narrowing of the airways, which leads to increased production of mucus. The excess mucus can block the airways and cause coughing, wheezing, and shortness of breath.
Emphysema:
Emphysema involves damage to the air sacs (Alveoli) in the lungs. The walls of the air sacs lose their elasticity, leading to a reduction in the surface area available for oxygen exchange. This results in shortness of breath and reduced oxygen supply to the body’s tissues.
Common symptoms of COPD:
- Persistent coughing, often with mucus production (a characteristic of chronic bronchitis)
- Shortness of breath, especially during physical activity
- Wheezing or noisy breathing
- Tightness in the chest
- Frequent respiratory infections
- Fatigue
- Unintended weight loss
COPD is a progressive disease, meaning it worsens over time and cannot be fully reversed. However, various treatments and lifestyle changes can help manage symptoms and slow down the disease progression:
Treatment and management:
- Lifestyle changes: Quitting smoking is the most important step in slowing down the progression of COPD. Avoiding exposure to lung irritants is also crucial.
- Medications: Bronchodilators (inhaled medications that help open the airways) and inhaled corticosteroids may be prescribed to alleviate symptoms.
- Pulmonary rehabilitation: This structured program includes exercise, education, and support to improve lung function and overall quality of life.
- Oxygen therapy: In cases of severe COPD, supplemental oxygen may be needed to improve oxygen levels in the blood.
- Surgery: In advanced cases, surgical options like lung volume reduction surgery or lung transplantation may be considered.
![Image](https://entrustclinicalresearch.com/wp-content/uploads/2021/03/COPD3.jpg)
Early diagnosis and proactive management are essential in minimizing the impact of COPD on an individual’s life. If you suspect you or someone you know might have COPD, it’s important to seek medical evaluation and guidance from a healthcare professional.